Di Matteo Scibilia
"In contrasto con studi epidemiologici e sperimentali, studi randomizzati sull'uso della vitamina D nella SM non hanno mostrato differenze significative nei parametri di attività della malattia - recidiva, progressione EDSS, e lesioni RM - tra il gruppo trattato con vitamina D e i gruppi che hanno ricevuto placebo o una dose minore di vitamina D."
Il risultato è che "non c'è evidenza scientifica, al momento, per l'uso della vitamina D come monoterapia per la SM nella pratica clinica".
ABSTRACT
Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. This review aimed to determine whether there is evidence to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We searched PUBMED, EMBASE, COCHRANNE, and LILACS databases for studies published until September 9 th , 2013, using the keywords “multiple sclerosis”, “vitamin D”, and “clinical trial”. There is no scientific evidence up to the production of this consensus for the use of vitamin D as monotherapy for MS in clinical practice.
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