Un team in gran parte composto da danesi ha recentemente pubblicato la prova di una forte associazione tra Sm e un retrovirus, insieme a sentori di un gene chiamato TRIM5, che viene utilizzato nelle cellule per combattere i virus, ed è particolarmente attivo nelle persone con SM.
Il virus che sembra implicato nella SM è chiamato HERV-Fc1, una strana "bestia" chiamata retrovirus endogeno. Questo significa che i suoi geni sono parte del genoma umano.
Bjørn Nexø della Aarhus University, scrive che "le infezioni retrovirali si sviluppano spesso nelle contiunue "battaglie" tra il sistema immunitario e il virus, con il virus che muta ripetutamente per evitare il sistema immunitario, e il sistema immunitario ripetutamente accelera. Si può vedere la natura episodica della sclerosi multipla in quanto tale come una battaglia in esecuzione."
La possibilità che si possono ereditare i geni di un virus confonde la distinzione tra una genetica e una malattia infettiva.I geni HERV-Fc1 si trovano sul cromosoma X. Dal momento che le donne hanno il doppio di cromosomi X rispetto agli uomini, questo potrebbe spiegarte perchè alcune forme di sclerosi multipla sono più comuni nelle donne. Il Dottor Nexø conclude speranzoso, dicendo che "la scoperta che una malattia è causata da un agente infettivo è incoraggiante, perchè sono le malattie che sappiamo meglio come trattare".
Fonte: http://www.msrc.co.uk/index.cfm/fuseaction/show/pageid/3392
The Wall Street Journal Copyright © 2012 Dow Jones & Company
A team largely made up of Denmark has recently published evidence of a strong association between MS and a retrovirus, with hints of a gene called TRIM5, which is used in cells to fight viruses, and is especially active in people with MS .
The virus that seems implicated in MS is called HERV-FC1, a strange "beast" called endogenous retroviruses. This means that its genes are part of the human genome.
Bjørn Nexø of Aarhus University, writes that "retroviral infections often develop in contiunue" battles "between the immune system and the virus, the virus that mutates repeatedly to avoid the immune system, immune system and accelerates again. You can see the episodic nature of MS itself as a running battle. "
The possibility that you may inherit the genes of a virus blurs the distinction between a gene and a disease infettiva.I HERV-FC1 genes are located on chromosome X. Since women are twice as X chromosomes than men, this could explain why some forms of multiple sclerosis are more common in women. Nexø concludes hopeful, saying that "the discovery that a disease is caused by an infectious agent is encouraging, because these are the diseases that we know better
how to deal with. "
http://www.msrc.co.uk/index.cfm/fuseaction/show/pageid/3392
A team largely made up of Denmark has recently published evidence of a strong association between MS and a retrovirus, with hints of a gene called TRIM5, which is used in cells to fight viruses, and is especially active in people with MS .
The virus that seems implicated in MS is called HERV-FC1, a strange "beast" called endogenous retroviruses. This means that its genes are part of the human genome.
Bjørn Nexø of Aarhus University, writes that "retroviral infections often develop in contiunue" battles "between the immune system and the virus, the virus that mutates repeatedly to avoid the immune system, immune system and accelerates again. You can see the episodic nature of MS itself as a running battle. "
The possibility that you may inherit the genes of a virus blurs the distinction between a gene and a disease infettiva.I HERV-FC1 genes are located on chromosome X. Since women are twice as X chromosomes than men, this could explain why some forms of multiple sclerosis are more common in women. Nexø concludes hopeful, saying that "the discovery that a disease is caused by an infectious agent is encouraging, because these are the diseases that we know better
how to deal with. "
http://www.msrc.co.uk/index.cfm/fuseaction/show/pageid/3392
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